Desensitization in HLA Incompatible Transplantation
نویسندگان
چکیده
منابع مشابه
Desensitization in HLA-incompatible kidney recipients and survival.
BACKGROUND More than 20,000 candidates for kidney transplantation in the United States are sensitized to HLA and may have a prolonged wait for a transplant, with a reduced transplantation rate and an increased rate of death. One solution is to perform live-donor renal transplantation after the depletion of donor-specific anti-HLA antibodies. Whether such antibody depletion results in a survival...
متن کاملOutcome after Desensitization in HLA or ABO-Incompatible Kidney Transplant Recipients: A Single Center Experience
BACKGROUND The shortage of deceased donors led to an increase of living donor kidney (LDK) transplantations performed in the presence of donor-specific antibodies (DSA) or ABO incompatibility (ABOi) using various desensitization protocols. METHODS We herein analyzed 26 ABOi and 8 Luminex positive DSA patients who were successfully desensitized by anti-CD20, antigen-specific immunoadsorption a...
متن کاملA closer look at rituximab induction on HLA antibody rebound following HLA incompatible kidney transplantation
Rituximab has been used to increase the efficacy of desensitization protocols for human leukocyte antigen (HLA)-incompatible kidney transplantation; however, controlled comparisons have not been reported. Here we examined 256 post-transplant HLA antibody levels in 25 recipients desensitized with and 25 without rituximab induction, to determine the impact of B-cell depletion. We found significan...
متن کاملABO-Incompatible Kidney Transplantation
ABO antigens are composed of sugar chains and exist not only on red cells but also on many other cells including endothelial cells and epithelial cells of various organs such as kidney, heart, bowel, lung, and pancreas (Marionneau et al., 2001). ABO antibodies, which have been called as isoagglutinins, are preformed antibodies directed against missing A or B antigens. The source of anti-A/B ant...
متن کاملABO-Incompatible Kidney Transplantation
ABO-incompatible (ABOi) kidney transplantation has long been considered a contraindication to successful kidney transplantation. During the last 25 years, increasing organ shortage enforced the development of strategies to overcome the ABO antibody barrier. In the meantime, ABOi kidney transplantation has become a routine procedure with death-censored graft survival rates comparable to the rate...
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ژورنال
عنوان ژورنال: The Korean Journal of Blood Transfusion
سال: 2019
ISSN: 1226-9336,2383-6881
DOI: 10.17945/kjbt.2019.30.1.1